Postcholecystectomy syndrome (PCS) refers to a group of symptoms that can occur after removal of the gallbladder (cholecystectomy). This can include abdominal pain, bloating, diarrhea, constipation, and reflux, among others. The exact cause of PCS is not well understood, but it is thought to be related to changes in the way bile is metabolized in the body after removal of the gallbladder. Some people may also experience changes in the gut microbiome after cholecystectomy, which may contribute to symptoms of PCS. Treatment options for PCS can vary and may include changes to diet and lifestyle, medications to manage specific symptoms, and in some cases, additional surgeries.