Antidepressants work by altering the levels of certain neurotransmitters in the brain, such as serotonin, which can affect both mood and gastrointestinal function. Some antidepressants, such as tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), have been shown to be effective in reducing symptoms of IBS, including abdominal pain, bloating, constipation, and diarrhoea.

It is important to note that while antidepressants can be effective in managing symptoms of IBS, they are not a cure for the condition. Additionally, it can take several weeks or even months for the full benefits of the medication to be realized, and some individuals may experience side effects from the medication.

Individuals with IBS who are considering taking antidepressants should work with their healthcare provider to determine the best course of treatment for their specific needs. It is also important to remember that while antidepressants can be effective in managing symptoms of IBS, they should be used in conjunction with other treatments, such as dietary changes, stress management techniques, and physical activity, to help manage symptoms and improve overall well-being.