Eosinophilic oesophagitis, commonly referred to as oesophageal asthma, is an uncommon condition that affects approximately one in 3,000 individuals in the United Kingdom. This disorder results in persistent inflammation of the tissue in the oesophagus, also known as the food pipe. While some individuals experience severe and distressing symptoms, others may only experience mild discomfort.

Postcholecystectomy syndrome (PCS) refers to a group of symptoms that can occur after removal of the gallbladder (cholecystectomy). This can include abdominal pain, bloating, diarrhea, constipation, and reflux, among others. The exact cause of PCS is not well understood, but it is thought to be related to changes in the way bile is metabolized in the body after removal of the gallbladder. Some people may also experience changes in the gut microbiome after cholecystectomy, which may contribute to symptoms of PCS. Treatment options for PCS can vary and may include changes to diet and lifestyle, medications to manage specific symptoms, and in some cases, additional surgeries.

Functional dyspepsia (FD) is a digestive disorder characterized by symptoms such as bloating, fullness, upper abdominal pain, nausea, and early feeling of fullness during or after eating. Unlike other digestive disorders, FD is not associated with any structural or biochemical abnormalities in the digestive system. The exact cause of FD is unknown, but some contributing factors may include:

Small intestine bacterial overgrowth (SIBO) is a condition in which there is an abnormal overgrowth of bacteria in the small intestine. The small intestine is typically relatively free of bacteria, but in SIBO, bacteria that are normally found in the large intestine migrate into the small intestine, where they can ferment carbohydrates and cause symptoms.

Common symptoms of SIBO include abdominal pain, bloating, diarrhea, constipation, and malnutrition. SIBO can also lead to nutrient deficiencies, as the bacteria in the small intestine can interfere with the normal absorption of nutrients.

SIBO is often caused by a dysfunction in the mechanisms that normally control the growth of bacteria in the small intestine, such as the ileocecal valve, which separates the small and large intestines, or the migrating motor complex (MMC), which helps to clear bacteria from the small intestine.

Risk factors for SIBO include conditions that slow down gut motility, such as diabetes and hypothyroidism, and the use of certain medications, such as proton pump inhibitors (PPIs), which reduce stomach acid.

The diagnosis of SIBO involves a breath test, in which the individual is asked to ingest a sugar solution and then breathe into a bag at intervals. The presence of elevated levels of certain gases in the breath indicates the presence of SIBO.

Treatment for SIBO typically involves a combination of dietary changes, antibiotics, and probiotics. It is important to work with a healthcare provider to develop a comprehensive treatment plan, as SIBO can be a complex and persistent condition.

Laryngopharyngeal reflux (LPR) is a type of acid reflux that occurs when stomach acid flows back into the larynx (voice box) and pharynx (throat). LPR is also known as silent reflux because many people with LPR do not experience the classic symptoms of acid reflux, such as heartburn.

Instead, people with LPR may experience symptoms such as:

Barrett’s esophagus is a condition in which the normal tissue lining the lower part of the esophagus (the tube that carries food from the mouth to the stomach) is replaced with abnormal tissue. It is a complication of gastroesophageal reflux disease (GERD), a condition in which stomach acid and other contents flow back into the esophagus.

The abnormal tissue in Barrett’s esophagus is believed to be a response to the irritation and damage caused by repeated exposure to stomach acid. In some cases, this abnormal tissue can develop into a type of pre-cancerous condition called dysplasia.

Symptoms of Barrett’s esophagus can include heartburn, difficulty swallowing, and chest pain. The condition is usually diagnosed through endoscopy, a procedure in which a lighted scope is used to examine the esophagus and stomach. Treatment for Barrett’s esophagus typically involves medications to control GERD and prevent further irritation to the esophagus, as well as periodic endoscopic surveillance to monitor for the development of dysplasia. In some cases, treatment may involve removal of the abnormal tissue.

IBD stands for Inflammatory Bowel Disease, which is a group of chronic disorders that cause inflammation of the digestive tract, including the large intestine (colon) and small intestine (small bowel). The two most common forms of IBD are Crohn’s disease and ulcerative colitis.

Crohn’s disease can affect any part of the digestive tract from the mouth to the anus, while ulcerative colitis affects only the colon. The symptoms of IBD can vary from person to person, but may include diarrhea, abdominal pain, weight loss, fatigue, and rectal bleeding. In severe cases, IBD can lead to malnutrition and other health problems.

The exact cause of IBD is not known, but it is believed to be a combination of genetic and environmental factors, including an abnormal immune response to the normal bacteria in the gut. There is no cure for IBD, but various treatments, including medication, surgery, and dietary changes, can help manage symptoms and prevent flares.